Nickel(0)-Catalyzed Cyclization of N-Benzoylaminals for Isoindolinone Synthesis

A nickel(0) catalyst effectively mediates the cyclization of N-benzoyl aminals in the presence of a stoichiometric Lewis acid. This method enables preparation of a variety of isoindolinones with substitution on the benzoyl fragment and C-3 carbon. This reaction likely proceeds via an α-amidoalkylnickel(II) intermediate, which then may cyclize via either an electrophilic aromatic substitution or an insertion pathway.

零价镍催化剂（nickel(0) catalyst）可在化学计量路易斯酸存在下，高效介导N-苯甲酰基缩醛胺的环化反应。该方法可制备一系列在苯甲酰基片段与C-3位碳原子上带有取代基的异吲哚啉酮。该反应大概率经由α-酰胺基烷基二价镍中间体（α-amidoalkylnickel(II) intermediate）进行，该中间体后续可通过亲电芳香取代反应或插入路径完成环化。