Farrell AJP_cell Supplemental figure 1.pdf
收藏Figshare2023-11-13 更新2026-04-08 收录
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Expression of the microRNA-17~92 cluster is up-regulated by aldosterone in mouse cortical collecting duct principal cells, exclusively in female mice. MiR-19 in this cluster targets the serum and glucocorticoid kinase (SGK1) to downregulate both mRNA and protein expression, resulting in a decrease in sodium transport across epithelial cells of the collecting duct. The miR-17~92 cluster is evolutionarily conserved and may act as a novel feedback regulator for aldosterone signaling in females. This supplement contains the species sequences used for phylogenetic analysis.
在小鼠皮质集合管主细胞（mouse cortical collecting duct principal cells）中，微小RNA-17~92簇（microRNA-17~92 cluster）的表达受醛固酮（aldosterone）上调，且该调控效应仅见于雌性小鼠。该簇中的miR-19可靶向血清和糖皮质激素激酶（SGK1），下调其信使RNA（mRNA）与蛋白质的表达水平，最终导致集合管上皮细胞的跨上皮钠转运能力降低。微小RNA-17~92簇在进化上具有保守性，可作为雌性个体中醛固酮信号通路的新型反馈调节因子。本补充数据集包含系统发育分析所用的物种序列。
提供机构：
Subramanya, Arohan; Bodnar, Andrew; Liu, Xiaoning; M. Cerqueira, Debora; Suda, Amanda; Ho, Jacqueline; Farrell, Corinne; Butterworth, Michael; Kashlan, Ossama B.; Ozbaki Yagan, Nejla
创建时间：
2023-11-13
