Profiling Methylomic Alterations in Postmortem Prefrontal Cortex Tissues of Individuals with Alcohol Use Disorders. Homo sapiens

Analysis of methylomic alternations related with alcohol use disorders (AUD). The hypothesis is that chronic alcohol consumption might alter genome-wide DNA methylation patterns. The results suggest that differential DNA methylation might be invovled in neuradaptations to alcohol. Overall design: Genomic DNA was extraced from postmortem prefrontal cortex tissues of 23 AUD cases and 23 matched controls. Both AUD cases and matched controls are assessed with DSM-IV

酒精使用障碍（Alcohol Use Disorders, AUD）相关甲基组改变分析。本研究假设长期饮酒可能会改变全基因组范围内的DNA甲基化模式。研究结果显示，差异性DNA甲基化或许参与了机体对酒精的神经适应性过程。实验设计：从23例酒精使用障碍患者与23例匹配对照者的死后前额叶皮层组织中提取基因组DNA，所有受试者均采用精神障碍诊断与统计手册第四版（Diagnostic and Statistical Manual of Mental Disorders Fourth Edition, DSM-IV）进行评估。