RNA-seq in mouse embryonic stem cells treated with or without Adriamycin

The tumor suppressor p53 is a well-recognized transcription factor that directly regulates transcriptional activation through sequence-specific DNA binding. However, whether p53 functions as a direct transcriptional repressor has long been debatable. Overall design: RNA-seq in mouse embryonic stem cells treated with or without Adriamycin

肿瘤抑制因子p53（tumor suppressor p53）是公认的转录因子（transcription factor），可通过序列特异性DNA结合直接调控转录激活。然而，p53是否可作为直接转录抑制因子发挥功能，长期以来一直存在争议。实验设计概述：对经阿霉素（Adriamycin）处理与未处理的小鼠胚胎干细胞开展RNA-seq检测。