Examination of mRNA decay rate in mature adipocytes

The CCR4-NOT deadenylase complex has a critical function to trigger mRNA decay and various biological events. To understand roles of the complex in adipocyte function, we compare mRNA half-lives between control and Cnot complex-deficient mature adipocytes from iWAT and BAT.

CCR4-NOT脱腺苷化酶复合物（CCR4-NOT deadenylase complex）具备触发mRNA降解与多种生物学事件的核心功能。为阐明该复合物在脂肪细胞功能中的作用，本研究对比了提取自腹股沟白色脂肪组织（inguinal white adipose tissue, iWAT）与棕色脂肪组织（brown adipose tissue, BAT）的对照组及Cnot复合物缺陷型成熟脂肪细胞的mRNA半衰期。