S1P Lyase Bacterial Surrogate bound to N-(1-(4-(3-hydroxyprop-1-yn-1-yl)phenyl)-2-((4-methoxy-2,5-dimethylbenzyl)amino)ethyl)-5-methylisoxazole-3-carboxamide

S1P Lyase Bacterial Surrogate bound to N-(1-(4-(3-hydroxyprop-1-yn-1-yl)phenyl)-2-((4-methoxy-2,5-dimethylbenzyl)amino)ethyl)-5-methylisoxazole-3-carboxamide Descriptor: PHOSPHATE ION, Putative sphingosine-1-phosphate lyase, ~{N}-[(1~{S})-2-[(4-methoxy-2,5-dimethyl-phenyl)methylamino]-1-[4-(3-oxidanylprop-1-ynyl)phenyl]ethyl]-5-methyl-1,2-oxazole-3-carboxamide Authors: Argiriadi, M.A, Banach, D, Radziejewska, E, Marchie, S, DiMauro, J, Dinges, J, Dominguez, E, Hutchins, C, Judge, R.A, Queeney, K, Wallace, G, Harris, C.M. Deposit date: 2015-11-18 Release date: 2016-03-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Creation of a S1P Lyase bacterial surrogate for structure-based drug design. Bioorg.Med.Chem.Lett., 26, 2016

结合了N-(1-(4-(3-羟基丙-1-炔-1-基)苯基)-2-((4-甲氧基-2,5-二甲基苄基)氨基)乙基)-5-甲基异恶唑-3-甲酰胺的S1P裂解酶（S1P Lyase）细菌替代蛋白
描述：磷酸根离子、推定的鞘氨醇-1-磷酸裂解酶，N-[(1S)-2-[(4-甲氧基-2,5-二甲基苯基)甲氨基]-1-[4-(3-羟基丙-1-炔基)苯基]乙基]-5-甲基-1,2-恶唑-3-甲酰胺
作者：Argiriadi, M.A, Banach, D, Radziejewska, E, Marchie, S, DiMauro, J, Dinges, J, Dominguez, E, Hutchins, C, Judge, R.A, Queeney, K, Wallace, G, Harris, C.M.
提交日期：2015-11-18
发布日期：2016-03-16
最后修改日期：2023-11-15
实验方法：X射线衍射（分辨率2.24 Å）
引用文献：《用于基于结构药物设计的S1P裂解酶细菌替代蛋白的构建》，Bioorg.Med.Chem.Lett., 26卷，2016年