GENEVA Prostate Cancer. GENEVA Prostate Cancer

Multiple GWA studies of prostate cancer conducted in European White populations are ongoing. These studies will continue to have a dramatic impact on our understanding of the contribution of common genetic variation on inter-individual susceptibility to this common cancer. Important questions that will remain unanswered, however, are whether all common risk alleles for prostate cancer will be revealed in studies limited to populations of European ancestry. A comprehensive examination of common genetic variation in men of Japanese, Latino, and African ancestry will be required to understand population differences in disease risk and to reveal the full spectrum of causal alleles that exist in these populations. Further, genetic and environmental diversity is likely to contribute to ethnic... (for more see dbGaP study page.)

多项针对欧洲白人人群的前列腺癌全基因组关联研究（Genome-Wide Association Study, GWA）正在进行中。此类研究将持续深刻影响我们对常见遗传变异在该常见癌症个体间易感性中作用的认知。然而，仍有若干关键问题尚未得到解答：仅针对欧洲血统人群开展的研究，是否能揭示前列腺癌全部的常见风险等位基因？若要明晰不同人群间疾病风险的差异，并揭示这些人群中存在的全部致病等位基因谱系，就需要对日本裔、拉丁裔及非洲裔男性的常见遗传变异开展全面分析。此外，遗传与环境多样性可能对族群……（更多详情请参见dbGaP研究页面）