Cardiovascular responses of peripheral artery disease patients during resistance exercise

BACKGROUND: Resistance training has been used for the treatment of patients with peripheral artery disease (PAD). However, cardiovascular responses during this type of exercise have not been fully elucidated in these patients. OBJECTIVES: To analyze the cardiovascular responses during resistance exercise and to verify whether there are any correlations between these responses and disease severity or blood pressure levels in patients with PAD. METHODS: Seventeen PAD patients performed one set of 10 repetitions of knee extension exercise with an intensity of 50% of one repetition maximum. The responses of systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were continuously monitored using the finger photoplethysmography technique. The rate-pressure product (RPP) was obtained by multiplication of SBP and HR. RESULTS: During the resistance exercises there were significant increases in SBP (126 ± 14 vs. 184 ± 20 mmHg, p<0.001), DBP (68 ± 8 vs. 104 ± 14 mmHg, p<0.001), HR (76 ± 18 vs. 104 ± 30 bpm, p<0.001) and RPP (9523 ± 2115 vs. 19103 ± 6098 mmHg x bpm, p<0.001). A negative correlation was observed between relative change (Δ) in SBP and SBP at rest (r =-0.549, p=0.022). On the other hand, there was no relationship between Δ SBP and the ankle-brachial index (r=0.076, p=0.771). CONCLUSION: Increases in cardiovascular variables were observed during resistance exercise in PAD patients. The highest increases occurred in patients with lower SBP levels at resting.

背景：阻力训练已被用于外周动脉疾病（PAD）患者的临床治疗。然而，此类运动过程中的心血管反应在该类患者中尚未得到充分阐明。
目的：分析PAD患者在阻力运动过程中的心血管反应，并验证此类反应与患者疾病严重程度或血压水平是否存在相关性。
方法：17名PAD患者完成1组膝关节伸展运动，每组重复10次，运动强度为单次最大重复重量（1RM）的50%。采用指光电容积描记技术持续监测收缩压（SBP）、舒张压（DBP）及心率（HR）的变化。通过收缩压与心率的乘积计算得到率压乘积（RPP）。
结果：阻力运动过程中，患者的收缩压（从126±14 mmHg升至184±20 mmHg，p<0.001）、舒张压（从68±8 mmHg升至104±14 mmHg，p<0.001）、心率（从76±18 bpm升至104±30 bpm，p<0.001）及率压乘积（从9523±2115 mmHg·bpm升至19103±6098 mmHg·bpm，p<0.001）均出现显著升高。研究观察到，收缩压相对变化量（Δ）与静息收缩压呈负相关（r=-0.549，p=0.022）。另一方面，收缩压相对变化量与踝肱指数无显著相关性（r=0.076，p=0.771）。
结论：PAD患者在阻力运动过程中，各项心血管指标均出现升高。静息收缩压水平较低的患者，其心血管指标升高幅度最为显著。