WHO near miss criteria adapted to the local context of HLH.

aShock is defined as a persistent severe hypotension, defined as a systolic blood pressure 2L).bOliguria is defined as an urinary output cFailure to form clots is defined as the absence of clotting from the IV site after 7–10 minutes.dUnconsciousness/coma lasting >12 hours is defined as a profound alteration of mental state that involves complete or near-complete lack of responsiveness to external stimuli or Glasgow Coma Scale eCardiac arrest is defined as loss of consciousness and absence of pulse or heart beat.fStroke is defined as a neurological deficit of cerebrovascular cause that persists ≥24 hours, or is interrupted by death within 24 hours.gUncontrollable fit is a condition in which the brain is in state of continuous seizure.hPre-eclampsia: the presence of hypertension associated with proteinuria. Hypertension is defined as a blood pressure ≥140 mmHg (systolic) or ≥90 mmHg (diastolic). Proteinuria is defined as excretion of ≥300 mg protein/24 hr or 300 mg protein/litre urine or ≥1+ on a dipstick.iEclampsia is defined as the presence of hypertension associated with proteinuria and fits. Hypertension is defined as a blood pressure ≥140 mmHg (systolic) or ≥90 mmHg (diastolic). Proteinuria is defined as excretion of ≥300 mg protein/24 hr or 300 mg protein/litre urine or ≥1+ on a dipstick.jSepsis is defined as a clinical sign of infection and 3 of the following: temp>38°C or 20/min, pulse rate >90/min, WBC >12.kUterine rupture is defined as the complete rupture of a uterus during labour.

a. 休克（Shock）：定义为持续性严重低血压，其判定标准为收缩压[原文疑似笔误，原内容为“2L)”]。
b. 少尿（Oliguria）：定义为尿量[原文定义未完整给出]。
c. 凝血障碍：定义为静脉穿刺部位（IV site）在7~10分钟后无凝血块形成。
d. 持续超过12小时的意识丧失/昏迷：定义为精神状态严重改变，表现为对外部刺激完全或几乎完全无反应，或格拉斯哥昏迷量表（Glasgow Coma Scale）[原文定义未完整给出]。
e. 心搏骤停（Cardiac arrest）：定义为意识丧失，且脉搏或心跳消失。
f. 脑卒中（Stroke）：定义为因脑血管病变引发的神经功能缺损，持续时间≥24小时，或在24小时内因该病变导致死亡。
g. 难治性癫痫发作（Uncontrollable fit）：指大脑处于持续癫痫发作状态的病症。
h. 子痫前期（Pre-eclampsia）：指合并蛋白尿（Proteinuria）的高血压（Hypertension）病症。高血压定义为收缩压≥140mmHg或舒张压≥90mmHg；蛋白尿定义为24小时尿蛋白排泄量≥300mg，或每升尿液中蛋白含量≥300mg，或尿蛋白试纸条（dipstick）检测结果≥1+。
i. 子痫（Eclampsia）：指合并蛋白尿和癫痫发作的高血压病症。高血压定义为收缩压≥140mmHg或舒张压≥90mmHg；蛋白尿定义为24小时尿蛋白排泄量≥300mg，或每升尿液中蛋白含量≥300mg，或尿蛋白试纸条检测结果≥1+。
j. 脓毒症（Sepsis）：定义为存在感染的临床征象，且满足以下至少3项指标：体温＞38℃、呼吸频率＞20次/分（原文表述为“temp>38°C or 20/min”）、脉搏＞90次/分、白细胞计数（WBC）＞12[原文未标注完整单位，推测为×10^9/L]。
k. 子宫破裂（Uterine rupture）：定义为分娩（Labour）过程中子宫完全破裂。