Single-cell profiling of environmental enteropathy reveals epithelial and immune dynamics

Here, we use the single-cell RNA-sequencing platform Seq-Well to generate a cellular atlas of environmental enteropathy in the proximal small intestine Single-cell RNA sequencing of proximal intestine samples from 11 patients with environmental enteropathy (EE) and 3 patients with eosinophilic esophagitis (EoE) and 2 patients with dysphagia from South Africa (SA)

本研究采用单细胞RNA测序（single-cell RNA-sequencing）平台Seq-Well，构建近端小肠环境性肠病的细胞图谱。本研究采集了来自南非（South Africa, SA）的11例环境性肠病（environmental enteropathy, EE）患者、3例嗜酸性食管炎（eosinophilic esophagitis, EoE）患者及2例吞咽困难（dysphagia）患者的近端小肠样本，并对上述样本开展单细胞RNA测序。