Additional file 8 of Pathological mechanisms and candidate therapeutic approaches in the hearing loss of mice carrying human MIR96 mutations

Additional file 8:  Table S7. Gene sets enriched in up- and downregulated genes in Mir96 Dmdo and Mir183/96 dko homozygotes. For each gene set, the number of the misregulated genes from the RNA-seq analysis is shown, along with enrichment score (based on the number of misregulated genes in the gene set, the total number of misregulated genes and the overall gene set size), normalised enrichment score (which accounts for gene set size), p value (significance of enrichment score for the single gene set) and false discovery rate (FDR; the probability that a gene set with that normalised enrichment score represents a false positive finding, corrected for multiple testing and gene set size). Gene sets are ordered by FDR. Transcriptome data are from [4] and [12].

补充文件8：附表S7。该附表展示了Mir96 Dmdo纯合突变体与Mir183/96 dko纯合突变体中上调及下调失调基因所富集的基因集。针对每个基因集，本表均列出了RNA测序（RNA-seq）分析中鉴定得到的失调基因的数量，同时附带富集得分（基于基因集中的失调基因数、总失调基因数以及基因集总大小计算）、标准化富集得分（已考虑基因集大小的影响）、p值（单个基因集富集得分的显著性水平）以及错误发现率（false discovery rate, FDR；即携带该标准化富集得分的基因集为假阳性结果的概率，该值经多重检验校正并针对基因集大小进行了校正）。基因集按错误发现率进行排序。转录组数据来源于文献[4]与[12]。