GSE86374 Expression Data

Analysis of somatic DNA copy number alterations and frequency of breast cancer intrinsic subtypes from Mexican women.

Breast cancer is a heterogeneous disease described in well-recognized biological subtypes. Particularly, gene expression profiling has revealed 5 intrinsic subtypes of breast cancer characterized by different biological and clinical features. The diversity of the intrinsic subtypes across human population has been limited described, and there is few information about the genomic architecture of breast tumors in Mexican or Hispanic populations. In this study, we performed PAM50 assay, based in Affymetrix microarray profiling of 128 fresh frozen tumors from Mexican Latino Hispanic population, to describe the overall distribution of subtypes, and characterize the relation to clinicopathologic characteristics.

墨西哥女性体细胞DNA拷贝数改变及乳腺癌固有亚型频率分析
乳腺癌是一类具有公认生物学亚型的异质性疾病。其中，基因表达谱分析已鉴定出5种乳腺癌固有亚型，各亚型均具备独特的生物学与临床特征。当前针对不同人群中乳腺癌固有亚型多样性的研究仍较为有限，且墨西哥裔或西班牙裔人群乳腺肿瘤的基因组结构相关信息亦十分匮乏。本研究针对墨西哥拉丁裔西班牙裔人群的128例新鲜冷冻肿瘤组织，开展基于Affymetrix基因芯片谱的PAM50检测（PAM50 assay），以明确该人群中乳腺癌亚型的整体分布特征，并解析其与临床病理特征的相关性。