Non-Invasive Magnetic Resonance Imaging in Rats for Prediction of the Fate of Grafted Kidneys from Cardiac Death Donors

The main objective of this study was to assess cardiac death (CD) kidney grafts before transplantation to determine whether blood oxygen level-dependent (BOLD) and diffusion MRI techniques can predict damage to these grafts after transplantation. We assessed CD kidney tissue by BOLD and diffusion MRI. We also examined pathological and gene expression changes in CD kidney grafts before and after transplantation. Although there was significantly more red cell congestion (RCC) in the inner stripe of the outer medulla (IS) in both 1 h after cardiac death (CD1h) and CD2h kidneys destined for grafts before transplantation compared with CD0h (p

本研究的核心目标为在移植前评估心脏死亡（cardiac death, CD）肾脏移植物，以明确血氧水平依赖（blood oxygen level-dependent, BOLD）与弥散磁共振成像技术能否预测此类移植物在移植后的损伤情况。我们通过BOLD成像与弥散磁共振成像对CD供体肾脏组织开展了评估。同时，我们还分析了移植前后CD供体肾脏移植物的病理学变化与基因表达改变。相较于心脏死亡后0小时（CD0h）的供体肾，拟用于移植的心脏死亡后1小时（CD1h）与心脏死亡后2小时（CD2h）供体肾的外髓质内带（IS）中红细胞淤积（RCC）程度显著更高（p