Table_1_Association Between White Blood Cells at Baseline and Treatment Failure of MTX for Ectopic Pregnancy.XLSX

Purpose: The aim of this study was to evaluate white blood cell (WBC) count as a risk factor related to methotrexate (MTX) treatment failure in patients with ectopic pregnancy (EP).
Methods: A total of 236 women diagnosed with EP and treated with a single dose of MTX were included. The exposure variable was WBC count at baseline, and the outcome was MTX treatment outcome. Both a multivariate binary logistics regression model and subgroup analysis were performed to evaluate the association between WBC and MTX non-response.
Results: WBC count was associated with the risk of treatment failure, and the odds ratio (OR) in different multivariate models was stable [minimally adjusted model: OR 1.2, 95% confidence interval (CI): 1.0–1.3, p = 0.008; fully adjusted model: OR 1.2, 95% CI: 1.0–1.4, p = 0.026]. For WBCs in group T3 (>8.9 × 109/L), the association between WBC count and treatment failure was significant (minimally adjusted model: OR: 2.0, 95% CI: 1.0–3.8, p = 0.050; fully adjusted model: OR: 2.2, 95% CI: 1.1–5.6, p = 0.034). Subgroup analysis showed that in participants with regular menstruation (OR 1.1, 95% CI: 1.0–1.3), WBC count was significantly different from irregular menstruation (OR 1.8, 95% CI: 1.2–2.8); p for interaction was 0.031.
Conclusions: We found a reliable and non-linear relationship between WBC count and MTX treatment failure for EP.

研究目的：本研究旨在评估白细胞（white blood cell, WBC）计数作为甲氨蝶呤（methotrexate, MTX）治疗异位妊娠（ectopic pregnancy, EP）失败相关风险因素的作用。
研究方法：本研究共纳入236例确诊为异位妊娠且接受单剂量甲氨蝶呤治疗的女性患者。暴露变量为基线白细胞计数，结局指标为甲氨蝶呤治疗结局。本研究采用多因素二元logistic回归模型及亚组分析，评估白细胞计数与甲氨蝶呤治疗无应答之间的关联。
研究结果：白细胞计数与治疗失败风险存在显著关联，不同多因素模型中的比值比（odds ratio, OR）结果均较为稳定[最小校正模型：OR=1.2，95%置信区间（confidence interval, CI）：1.0~1.3，p=0.008；完全校正模型：OR=1.2，95%CI：1.0~1.4，p=0.026]。对于T3组白细胞（>8.9×10^9/L），白细胞计数与治疗失败的关联具有统计学意义[最小校正模型：OR=2.0，95%CI：1.0~3.8，p=0.050；完全校正模型：OR=2.2，95%CI：1.1~5.6，p=0.034]。亚组分析显示，在月经规律的受试者中（OR=1.1，95%CI：1.0~1.3），其白细胞计数与月经不规则受试者（OR=1.8，95%CI：1.2~2.8）的结果存在显著差异；交互作用p值为0.031。
研究结论：本研究发现，异位妊娠患者的白细胞计数与甲氨蝶呤治疗失败之间存在可靠的非线性关联。