BOston Neonatal Brain Injury Data for Hypoxic Ischemic Encephalopathy (BONBID-HIE): I. MRI and Manual Lesion Annotation

BOston Neonatal Brain Injury Dataset for Hypoxic Ischemic Encephalopathy (BONBID-HIE): Part I. MRI and Manual Lesion Annotation Hypoxic ischemic encephalopathy (HIE) is a brain injury that occurs in 1 ∼ 5/1000 term neonates. Accurate identification and segmentation of HIE-related lesions in neonatal brain magnetic resonance images (MRIs) is the first step toward predicting prognosis, identifying high-risk patients, and evaluating treatment effects. It will lead to a more accurate estimation of prognosis, a better understanding of neurological symptoms, and a timely prediction of response to therapy. We release the first public dataset containing neonatal brain diffusion MRI and expert annotation of lesions from 133 patients diagnosed with HIE. HIE-related lesions in brain MRI are often diffuse (i.e., multi-focal), and small (over half the patients in our data having lesions occupying <1% of brain volume). Segmentation for HIE MRI data is remarkably different from, and arguably more challenging than, other segmentation tasks such as brain tumors with focal and relatively large lesions. We hope that this dataset can help fuel the development of MRI lesion segmentation methods for HIE and small diffuse lesions in general. Contact: Rina Bao: [e-mail] Yangming Ou: [e-mail] License: All data has been made publicly available under the CC BY license (https://creativecommons.org/licenses/by/4.0/legalcode). If you use this data, please cite our paper:@article{bao2023boston, title={BOston Neonatal Brain Injury Dataset for Hypoxic Ischemic Encephalopathy (BONBID-HIE): Part I. MRI and Manual Lesion Annotation}, author={Bao, Rina and Song, Ya’nan and Bates, Sara V and Weiss, Rebecca J and Foster, Anna N and Cobos, Camilo Jaimes and Sotardi, Susan and Zhang, Yue and Gollub, Randy L and Grant, P Ellen and others}, journal={bioRxiv}, year={2023}, publisher={Cold Spring Harbor Laboratory Preprints}}《波士顿新生儿缺氧缺血性脑病脑损伤数据集（BONBID-HIE）：第一部分：磁共振成像与病变手动标注》 缺氧缺血性脑病（Hypoxic Ischemic Encephalopathy, HIE）是一种每1000名足月新生儿中约有1至5名罹患的脑损伤。对新生儿脑磁共振成像（Magnetic Resonance Imaging, MRI）中的HIE相关病变进行精准识别与分割，是预测预后、甄别高危患儿及评估治疗效果的首要步骤。此举可助力实现更精准的预后评估、更深入的神经系统症状认知，以及对治疗响应的及时预判。 本研究发布首个公开数据集，涵盖133名确诊HIE患儿的新生儿脑弥散磁共振成像（diffusion MRI）数据及病变专家标注结果。HIE相关脑MRI病变通常呈弥漫性（即多灶性）且体积微小：本数据集中超半数患儿的病变体积占脑容积比例不足1%。与局灶性、体积较大的脑肿瘤分割等其他分割任务相比，HIE磁共振成像数据的分割任务不仅差异显著，更堪称难度更高的挑战。我们希望本数据集能够推动HIE及一般性弥漫性微小病变的MRI病变分割方法研发。 联系方式：鲍丽娜（Rina Bao）：[e-mail]；欧阳明（Yangming Ou）：[e-mail] 授权协议：所有数据已采用CC BY许可协议（https://creativecommons.org/licenses/by/4.0/legalcode）公开发布。 若使用本数据集，请引用以下论文： @article{bao2023boston, title={波士顿新生儿缺氧缺血性脑病脑损伤数据集（BONBID-HIE）：第一部分：磁共振成像与病变手动标注}, author={Bao, Rina and Song, Ya’nan and Bates, Sara V and Weiss, Rebecca J and Foster, Anna N and Cobos, Camilo Jaimes and Sotardi, Susan and Zhang, Yue and Gollub, Randy L and Grant, P Ellen and others}, journal={bioRxiv}, year={2023}, publisher={Cold Spring Harbor Laboratory Preprints} }