Kosakonia radicincitans with hypervirulent lON genes causes human bloodstream infections - supplementary - materials

Kosakonia radicincitans is a species within the new genus Kosakonia, which is typically a plant pathogen,
with rare reports of human infection. The number of human infections may be underestimated
because this new genus is under-represented among diagnostic tools. This report describes a case of
bloodstream infection caused by K. radicincitans. The pathogen was identified by matrix-assisted laser
desorption/ionization-TOF mass spectrometry and 16S rRNA gene sequencing. The hypervirulent human
pathogenicity gene LON, which has not been described before, was detected in the bacterial genome by
gene annotation. Thus, this discovery provides a new reference for studying the pathogenic mechanism
of this rare pathogen.

Kosakonia radicincitans，作为一种新分类的Kosakonia属成员，通常为植物病原体，人类感染病例罕见。由于该新属在诊断工具中的代表性不足，可能导致人类感染病例的统计低估。本报告详细描述了一例由K. radicincitans引起的血液感染病例。病原体通过基质辅助激光解吸/电离-飞行时间质谱和16S rRNA基因测序方法被鉴定。在细菌基因组中，通过基因注释首次发现了高度致病性的人源致病基因LON。因此，这一发现为研究此罕见病原体的致病机制提供了新的参考依据。