Analysis of gene expression profile in photoreceptor-like cells derived from fibroblasts. Analysis of gene expression profile in photoreceptor-like cells derived from fibroblasts

To clarify disease-specific profiles, we employed DNA microarray analysis using induced photoreceptor-like cells derived from fibroblasts. Overall design: Using induced photoreceptor-like cells by CRX, RAX, NeuroD, and OTX2, we employed DNA microarray analysis to compare expression levels of disease-related genes in fibroblasts.

为明确疾病特异性表达谱，本研究采用源自成纤维细胞的诱导型感光细胞样细胞开展DNA微阵列分析。实验整体设计：以经CRX、RAX、NeuroD及OTX2诱导生成的感光细胞样细胞为材料，通过DNA微阵列分析对比成纤维细胞中疾病相关基因的表达水平。