Identification of interleukin-4 (IL-4) targets in chronic lymphocytic leukemia (CLL)

ChEBI2014-10-06 更新2026-07-21 收录

淋巴细胞白血病分子机制

细胞因子靶点发现

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-55288 数据链接链接失效反馈

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Identification of interleukin-4 (IL-4) targets in chronic lymphocytic leukemia (CLL)

创建时间：

2014-10-06

CD8+ T-cell exhaustion induced by leukemic cells drives progression in Chronic Lymphocytic Leukemia

淋巴细胞白血病分子机制

肿瘤免疫微环境中T细胞耗竭

Mechanisms mediating to disease progression from diagnosis in chronic lymphocytic leukemia (CLL) are not fully elucidated. The acquisition of molecular changes at the time of progression has been obse

NIAID Data Ecosystem50

RBPJ and H3K27ac chromatin IP with sequencing of CLL cells with hyperactivated Notch1 compared to control CLL cells [ChIP-seq]. RBPJ and H3K27ac chromatin IP with sequencing of CLL cells with hyperactivated Notch1 compared to control CLL cells [ChIP-seq]

淋巴细胞白血病分子机制

Notch信号通路

NOTCH1 gain-of-function mutations are recurrent in B cell chronic lymphocytic leukemia (B-CLL), where they are associated with accelerated disease progression and refractoriness to chemotherapy. The s

NIAID Data Ecosystem30

siRNA-mediated silencing of ETV6/RUNX1 increases the level of mature miR-181a-1.

淋巴细胞白血病分子机制

miRNA调控

(A) Stem-loop sequence of human precursor mir-181a-1. Mature miR-181a (red) and miR181a-1 (blue) are indicated. (B) Validation of miR-181a-1 expression in primary pre-B ALL samples (ETV6/RUNX1-positiv

NIAID Data Ecosystem20

Homo sapiens

淋巴细胞白血病分子机制

microRNA靶基因

MicroRNAs are known to inhibit gene expression by binding to the 3Â´UTR of the target transcript. Downregulation of miR-223 has been recently reported to have prognostic significance in CLL. However,

NIAID Data Ecosystem30

PI3K/AKT pathway is activated by miRNA-22 in the proliferative CLL subset (miRNA). Homo sapiens

淋巴细胞白血病分子机制

PI3K/AKT信号通路

Understanding the crosstalk between malignant B-cells and their milieu could provide clues on the molecular and clinical biology of Chronic Lymphocytic Leukemia (CLL). Aiming to generate novel therape

NIAID Data Ecosystem20

Identification of interleukin-4 (IL-4) targets in chronic lymphocytic leukemia (CLL)

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