Treatment direct and indirect cost estimates.

Managing tibial fractures requires substantial health resources, which costs the health system. This study aimed to describe the costs of photobiomodulation (PBM) with LEDs in the healing process of soft tissue lesions associated with tibial fracture compared to a placebo. Economic analysis was performed based on a randomized controlled clinical trial, with a simulation of the cost-effectiveness and incremental cost model. Adults (n = 27) hospitalized with tibia fracture awaiting definitive surgery were randomized into two distinct groups: the PBM Group (n = 13) and the Control Group with simulated phototherapy (n = 14). To simulate the cost-effectiveness and incremental cost model, the outcome was the evolution of wound resolution by the BATES-JENSEN scale and time of wound resolution in days. The total cost of treatment for the Control group was R$21,164.56, and a difference of R$7,527.10 more was observed when compared to the treatment of the PBM group. The proposed intervention did not present incremental cost since the difference in the costs to reduce measures between the groups was smaller for the PBM group. When analyzing the ICER (Incremental cost-effectiveness ratio), it would be possible to save R$3,500.98 with PBM and decrease by 2.15 points in the daily average on the BATES-JENSEN scale. It is concluded, therefore, that PBM can be a supportive therapy of clinical and economic interest in a hospital setting.

胫骨骨折的诊疗需消耗大量医疗资源，给医疗系统带来沉重经济负担。本研究旨在对比光生物调节（photobiomodulation, PBM）联合LED照射与安慰剂对照在胫骨骨折相关软组织损伤愈合过程中的成本情况。本研究基于一项随机对照临床试验开展经济学分析，并对成本效用与增量成本模型进行了模拟。本研究纳入27名因胫骨骨折住院且等待确定性手术的成年患者，将其随机分为两组：光生物调节组（PBM组，n=13）与模拟光疗对照组（n=14）。本次建模中，结局指标采用BATES-JENSEN量表评估伤口愈合进展情况，并以伤口愈合天数作为衡量标准。对照组治疗总费用为21164.56雷亚尔，较PBM组高出7527.10雷亚尔。本研究提出的干预措施未产生增量成本，原因在于PBM组在降低相关指标方面的成本差异更小。在对增量成本效用比（incremental cost-effectiveness ratio, ICER）进行分析后发现，采用PBM治疗可节省3500.98雷亚尔，且BATES-JENSEN量表日均评分可降低2.15分。综上，光生物调节疗法可作为一种兼具临床与经济价值的辅助治疗手段，适用于医院临床场景。