Enhanced efficacy of aurora kinase inhibitors in G2/M checkpoint deficient TP53 mutant uterine carcinomas is linked to the summation of LKB1-AKT-p53 interactions [WGS]

We report bulk RNA sequencing, low pass whole genome sequencing, and targeted exome sequencing data of six uterine cancer organoids and show how specific molecular defects in these organoids make them sensitive to cell cycle targeting therapies. Transcriptomic and genomic sequencing of uterine cancer organoids.

本研究报道了6株子宫癌类器官（uterine cancer organoids）的批量RNA测序（bulk RNA sequencing）、低覆盖度全基因组测序（low pass whole genome sequencing）及靶向外显子组测序（targeted exome sequencing）数据，并阐明了此类类器官中特定的分子缺陷如何使其对细胞周期靶向治疗产生敏感性。本数据集涵盖子宫癌类器官的转录组测序与基因组测序数据。