Formation of Ragulator complex

A complex of LAMTOR1 to 5, known as Ragulator, interacts with Rag GTPases recruiting them to lysosomes, an essential step in mTORC1 activation (Sancak et al. 2010). LAMTOR1 is probably myristoylated and/or palmitoylated to enhance its assocation with the lysosomal surface, acting as a platform for the other members of the compex. Lamtor1 (Nada et al. 2009) and Lamtor2 (Teis et al. 2006) knockout mice exhibit severe growth retardation, severe defects in intracellular organelle organization and embryonic lethality. Partial reduction of LAMTOR2 in humans leads to reduced height (Bohn et al. 2007).

LAMTOR1至5复合体，亦称Ragulator，与Rag GTPase相互作用，将其募集至溶酶体中，这是mTORC1激活的关键步骤（Sancak等，2010年）。LAMTOR1可能通过棕榈酰化和/或芥子酰化增强其与溶酶体表面的结合，从而作为该复合体其他成员的平台。Lamtor1（Nada等，2009年）和Lamtor2（Teis等，2006年）敲除小鼠表现出严重的生长迟缓、严重的细胞器组织缺陷以及胚胎致死性。人类LAMTOR2的部分减少导致身高降低（Bohn等，2007年）。