Frequency of peri-intraventricular hemorrhage and its associated factors in premature newborns

ABSTRACT Objective: To identify the frequency of intracranial hemorrhage and its associated factors in premature newborns. Methods: A cross-sectional study based on a survey of medical records of premature neonates submitted to transfontanellar ultrasound at a hospital located in a southern neighborhood of the city of São Paulo, in 2007. Results: A 50% rate of intracranial hemorrhage was found among premature newborns submitted to transfontanellar ultrasound, and 15.35% among all premature babies born in this hospital in 2007. The statistically significant factors associated to intracranial hemorrhage were gestational age less than 32 weeks, absence of prenatal care, invasive mechanical ventilation, infection, blood transfusion, hyaline membrane disease, hyponatremia and hyperglycemia. Conclusions: The frequency of peri-intraventricular hemorrhage was 50% in patients at risk and 15.35% among all premature babies; the associated factors were gestational age less than 32 weeks, absence of prenatal care, need of invasive mechanical ventilation, infection, blood transfusion, hyaline membrane disease, hyponatremia and hyperglycemia.

摘要
研究目的：明确早产新生儿颅内出血（intracranial hemorrhage）的发生频率及其相关影响因素。
研究方法：本研究为横断面研究，基于2007年圣保罗市南部某医院收治的、接受经囟门超声（transfontanellar ultrasound）检查的早产新生儿的病历调查数据开展研究。
研究结果：在接受经囟门超声检查的早产新生儿中，颅内出血检出率为50%；2007年该医院所有早产新生儿中，颅内出血总发生率为15.35%。与颅内出血存在统计学关联的影响因素包括胎龄小于32周、未接受产前保健、行有创机械通气、合并感染、接受输血治疗、患有肺透明膜病（hyaline membrane disease）、低钠血症及高血糖症。
研究结论：本研究中高危早产新生儿的脑室周围-脑室内出血（peri-intraventricular hemorrhage）检出率为50%，该医院2007年所有早产新生儿的该类出血总发生率为15.35%；相关影响因素包括胎龄小于32周、需接受有创机械通气、合并感染、输血治疗、肺透明膜病、低钠血症及高血糖症。