Basal metabolic rate in Brazilian patients with type 2 diabetes: comparison between measured and estimated values

ABSTRACT Objectives: The aims of this study are to investigate which of the seven selected predictive equation for estimating basal metabolic rate (BMR) is the best alternative to indirect calorimetry (IC) and to evaluate the dietary energy intake in patients with type 2 diabetes. Subjects and methods: Twenty-one patients with type 2 diabetes participated in this diagnostic test study. Clinical and laboratorial variables were evaluated as well as body composition by absorptiometry dual X-ray emission (DXA) and BMR measured by IC and estimated by prediction equations. Dietary intake was evaluated by a quantitative food frequency questionnaire. Data were analyzed using Bland–Altman plots, paired t-tests, and Pearson's correlation coefficients. Results: Patients were 62 (48-70) years old, have had diabetes for 8 (2-36) yeas, and 52.4% were females. The mean body composition comprised a fat-free mass of 49.8 ± 9.4 kg and a fat mass of 28.3 ± 7.2 kg. The energy intake was 2134.3 ± 730.2 kcal/day and the BMR by IC was 1745 ± 315 kcal/day. There was a wide variation in the accuracy of BMR values predicted by equations when compared to IC BMR measurement. Harris-Benedict, Oxford, FAO/WHO/UNO equations produced the smallest differences to IC, with a general bias of

摘要 研究目的：本研究旨在探究七种已选定的基础代谢率（basal metabolic rate, BMR）预测方程中，哪一种可作为间接测热法（indirect calorimetry, IC）的最佳替代方案，同时评估2型糖尿病患者的膳食能量摄入情况。研究对象与方法：本项诊断试验研究共纳入21名2型糖尿病患者。研究人员对受试者的临床及实验室变量进行了评估，同时采用双能X线吸收法（dual X-ray emission absorptiometry, DXA）测定身体成分，并通过间接测热法实测基础代谢率，再利用各预测方程估算基础代谢率。膳食摄入情况通过定量食物频率问卷进行评估。数据分析采用布兰德-奥特曼（Bland–Altman）图、配对t检验以及皮尔逊相关系数。研究结果：受试者年龄中位数为62岁（四分位距48~70岁），糖尿病病程中位数为8年（四分位距2~36年），其中女性占比52.4%。受试者身体成分平均指标为：去脂体重49.8±9.4 kg，脂肪体重28.3±7.2 kg。日均能量摄入为2134.3±730.2 kcal，间接测热法实测的基础代谢率为1745±315 kcal/天。与间接测热法实测的基础代谢率相比，各预测方程所得的基础代谢率预测值准确性存在较大差异。哈里斯-本尼迪克特（Harris-Benedict）、牛津以及FAO/WHO/UNO方程与间接测热法的差值最小，整体偏倚为