Blood plasma profile after DOX treatment.

#For troponin I analysis, only 13 and 16 samples were measured in acute and sub-chronic protocol, respectively due to limitations in the analytical kit used.Differences between treatment groups means within the same model were evaluated by Student’s t test, when assumptions were not achieved a Welch correction or the non-parametric Mann-Whitney test were applied (see Material and Methods for detailed information).*p≤0.05;**p≤0.01;***p≤0.001 vs saline group of the same model. List of abbreviations: CK – creatine kinase; TnI – troponin I; TRIG – triglycerides; CHOL – total cholesterol; AST – aspartate aminotransferase; ALT – alanine aminotransferase; TP – total serum proteins; LDH – lactate dehydrogenase; CREA – creatinine; UA – uric acid; BUN – blood urea nitrogen; SE – standard error.

针对肌钙蛋白I（troponin I）的分析，由于所用分析试剂盒存在局限性，急性和亚慢性实验方案中分别仅检测了13和16份样本。同一实验模型内各治疗组的均值差异采用学生t检验进行评估，若不满足检验假设，则采用Welch校正或非参数曼-惠特尼检验（详细信息参见材料与方法部分）。*p≤0.05；**p≤0.01；***p≤0.001，与同一模型的生理盐水对照组相比。缩写列表如下：CK——肌酸激酶（creatine kinase）；TnI——肌钙蛋白I（troponin I）；TRIG——甘油三酯（triglycerides）；CHOL——总胆固醇（total cholesterol）；AST——天冬氨酸氨基转移酶（aspartate aminotransferase）；ALT——丙氨酸氨基转移酶（alanine aminotransferase）；TP——血清总蛋白（total serum proteins）；LDH——乳酸脱氢酶（lactate dehydrogenase）；CREA——肌酐（creatinine）；UA——尿酸（uric acid）；BUN——血尿素氮（blood urea nitrogen）；SE——标准误（standard error）。