Data_Sheet_1_Association Between Low Muscle Mass and Gastric Hyperplastic and Inflammatory Polyps in Chinese Asymptomatic Adult Males.CSV

BackgroundGastric polyp is an abnormally proliferative or neoplastic growth of the gastric mucosa, with a degree of tendency to transform into gastric cancer. Lack of physical activity that is significantly related to low muscle mass (LMM) and muscle strength has been identified to be associated with gastric polyps. In this study, we examine the association of LMM and different histological types of gastric polyps among Chinese asymptomatic adult males.
MethodsIn total, 1,742 male adults undergoing bioelectrical impedance analysis and upper gastrointestinal endoscopies were included. Univariate and multivariate logistic regression models were used to analyze the effect of LMM on the risk of gastric polyps and different histological types.
ResultsBy univariate and multivariate analyses, LMM (OR: 1.689, 95%CI: 1.046–2.726, p = 0.032) kept independent effect on risk of gastric polyps. When ratio of appendicular skeletal muscle mass to body mass index(ASM/BMI) was brought into the analyses, it was identified to be negatively correlated with occurrence of gastric polyps (OR: 0.744, 95%CI: 0.566–0.977, p = 0.033). For different pathological types, LMM showed different effect on occurrence of gastric polyps. LMM was an independent indicator for hyperplastic and inflammatory polyps (OR: 2.378, 95%CI: 1.288–4.389, p = 0.006), rather than fundic gland polyps (OR: 1.013, 95%CI: 0.473–2.173, p = 0.973).
ConclusionIn general, LMM was an independent indicator for hyperplastic and inflammatory polyps occurrence in Chinese asymptomatic adult males.

背景：胃息肉是指胃黏膜出现异常增生或赘生性生长，具有向胃癌转化的潜在癌变倾向。现有研究证实，体力活动缺乏与肌肉量低下（low muscle mass, LMM）及肌肉力量下降显著相关，且该因素与胃息肉的发生存在关联。本研究旨在探讨中国无症状成年男性群体中，LMM与不同组织学类型胃息肉的相关性。
方法：本研究共纳入1742名接受生物电阻抗分析（bioelectrical impedance analysis）及上消化道内镜检查（upper gastrointestinal endoscopies）的成年男性。采用单因素及多因素logistic回归模型，分析LMM对胃息肉及不同组织学类型胃息肉发生风险的影响。
结果：经单因素及多因素分析显示，LMM（比值比（odds ratio, OR）：1.689，95%置信区间（confidence interval, CI）：1.046–2.726，P=0.032）对胃息肉的发生风险具有独立影响。将四肢骨骼肌质量（appendicular skeletal muscle mass, ASM）与体质量指数（body mass index, BMI）之比（ASM/BMI）纳入分析后发现，该指标与胃息肉的发生呈负相关（OR：0.744，95%CI：0.566–0.977，P=0.033）。针对不同病理类型的胃息肉，LMM的影响存在差异：LMM是增生性息肉与炎性息肉（hyperplastic and inflammatory polyps）发生的独立预测指标（OR：2.378，95%CI：1.288–4.389，P=0.006），而非胃底腺息肉（fundic gland polyps）（OR：1.013，95%CI：0.473–2.173，P=0.973）。
结论：综上，在中国无症状成年男性群体中，LMM是增生性与炎性息肉发生的独立预测指标。