STAT2敲除小鼠
收藏中国科技资源共享网2022-07-19 更新2026-01-30 收录
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https://escience.org.cn/metadata/detail?cstrId=CSTR:16397.09.0G01000182&id=26630287602500d27cbe230ad26d616e:CSTR:16397.09.0G01000182
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资源简介：
Stat2敲除小鼠在免疫反应会表现出缺陷，增加对病毒感染的易感性。利用 CRISPR 技术剪切目标基因 Stat2 的蛋白编码区，小鼠受精卵细胞通过 NHEJ 的DNA 修复 ,在蛋白编码区产生移码突变， 使得 Stat2 蛋白失活，从而实现 Stat2 基因敲除的目的
Stat2 knockout mice exhibit immune response defects and increased susceptibility to viral infections. The protein-coding region of the target gene Stat2 was cleaved via CRISPR technology. Mouse fertilized eggs underwent NHEJ-mediated DNA repair, which induced frameshift mutations within the protein-coding region, leading to the inactivation of the Stat2 protein and ultimately achieving Stat2 gene knockout.
提供机构：
国家人类疾病动物模型资源库
创建时间：
2021-06-09
