IBS BAG

The IBS BAG includes in this proposal IBS teams and external groups from iRTSV/CEA (Grenoble), CEA-Cadarache (St Paul lez Durance) and IRBA (Brétigny-sur-Orge). We study structure-function relationships of proteins emphasizing in human health, biotechnology and methodology. Most of the projects are a continuation of the MX-2329 proposal and can be grouped in different topics as follows: host-pathogen interaction, new drug targets, fundamental cellular mechanisms, membrane proteins, intrinsically disordered proteins, biotechnological applications and methodology. Some of these projects use integrative approaches (X-ray crystallography, SAXS, NMR (and cryo-EM), together with other biophysical studies) with the aim to fully understand the complexity of the biological macromolecular systems on study. Some teams are dedicated to serial crystallography and its developments, for which the ESRF-EBS has become the perfect tool.

IBS BAG在本提案中涵盖了IBS团队及来自iRTSV/CEA（格勒诺布尔）、CEA-卡达拉什（圣保罗莱兹迪朗斯）和IRBA（布雷蒂尼叙尔奥尔日）的外部合作组。我们研究蛋白质的结构-功能关系，重点关注人类健康、生物技术及方法学领域。大多数项目是MX-2329提案的延续，可分为以下不同主题：宿主-病原体相互作用（host-pathogen interaction）、新型药物靶点、基础细胞机制、膜蛋白、内在无序蛋白（intrinsically disordered proteins）、生物技术应用及方法学。部分项目采用整合方法（包括X射线晶体学（X-ray crystallography）、小角X射线散射（SAXS）、核磁共振（NMR）及冷冻电镜（cryo-EM）），结合其他生物物理研究，旨在全面理解所研究生物大分子系统的复杂性。部分团队致力于串行晶体学（serial crystallography）及其发展，ESRF-EBS（欧洲同步辐射装置-极亮光源）已成为该领域的理想工具。