Omics analysis of Memory Regulatory T cells in a Recurrent Malaria Model

We investigate the molecular signatures of murine memory T regulatory cells in recurrent malaria episodes. We use a multi-omic approach, namely, single-cell RNA profiling and DNA methylation profiling, to gain deeper insights into the molecular factors associated with the transition of memory T regulatory cells to Tfh-like effectors cells after infection with Plasmodium chaubaudi chaubaudi, an etiological agent of rodent malaria.

本研究探讨了复发性疟疾发作过程中小鼠记忆性调节性T细胞（memory T regulatory cells）的分子特征。我们采用多组学方法，即单细胞RNA谱分析与DNA甲基化谱分析，以深入解析感染查氏疟原虫查氏亚种（Plasmodium chaubaudi chaubaudi，一种啮齿类疟疾致病原）后，记忆性调节性T细胞向滤泡辅助T细胞样效应细胞转化相关的分子因素。