Activity of BMS-284756, a Novel Des-Fluoro(6) Quinolone, against Staphylococcus aureus, Including Contributions of Mutations to Quinolone Resistance

The in vitro activity of BMS-284756 against 602 Staphylococcus aureus isolates, including 152 that were both methicillin and ciprofloxacin resistant (MIC ≥4 μg/ml), was determined. For ciprofloxacin-susceptible and nonsusceptible isolates, the MICs at which 50% of organisms were inhibited were 0.015 and 2 μg/ml and the MICs at which 90% of organisms were inhibited were 0.03 and 4 μg/ml, respectively.

本研究测定了BMS-284756对602株金黄色葡萄球菌（Staphylococcus aureus）分离株的体外抗菌活性，其中152株为同时耐甲氧西林（methicillin）与环丙沙星（ciprofloxacin）的菌株，其最低抑菌浓度（MIC）≥4μg/ml。针对环丙沙星敏感与非敏感的分离株，50%受试菌被抑制时的最低抑菌浓度分别为0.015μg/ml与2μg/ml；90%受试菌被抑制时的MIC则分别为0.03μg/ml与4μg/ml。