Supplementary Material for: Systematic Review of Health-Related Quality of Life in Adolescents with Psoriasis

<i>Background:</i> Many cases of psoriasis begin in adolescence. The affected adolescents face the combined physical and psychosocial challenges of their disease-free peers with the added complexity of a visible disease. <i>Objective:</i> To review the impact of psoriasis on the health-related quality of life (HRQL) in adolescents as compared to their peers with other chronic diseases and to determine the best tools to measure HRQL in this population. <i>Methods:</i> A systematic literature review was completed using PubMed. <i>Results:</i> 256 publications were screened for inclusion, 37 were relevant to objectives and included in the systematic review. Most studies are pediatric psoriasis studies with an adolescent subgroup, very few are dedicated to solely addressing HRQL in adolescents with psoriasis. Adolescents with psoriasis face both the challenges similar to an adult psoriasis population in addition to the complexities inherent to healthy adolescents. Studies often use a general pediatric HRQL measure, PedsQL 4.0, or a dermatology-specific measure adapted from an adult questionnaire. Only one psoriasis-specific measurement tool exists, and it is specifically for scalp psoriasis. <i>Conclusion:</i> Both dermatologists and primary care physicians should treat the visible cutaneous lesions and disease comorbidities and address the psychosocial impact of psoriasis in their adolescent patients. Use of both a general and dermatology-specific HRQL questionnaire may allow physicians to better identify the impact of the disease and recognize improvement or impairment over time.

<i>背景：</i>多数银屑病（psoriasis）病例起病于青少年时期。患病青少年不仅要面对与健康同龄人相同的生理与心理社会挑战，还要额外承受因可见性皮肤病带来的复杂困境。<i>目标：</i>对比银屑病青少年与其他慢性病同龄患者的银屑病对其健康相关生活质量（health-related quality of life, HRQL）的影响，并确定适用于该人群的最佳健康相关生活质量评估工具。<i>方法：</i>本研究通过PubMed数据库开展系统文献综述。<i>结果：</i>本研究共筛选256篇文献，其中37篇符合研究目标并纳入本次系统综述。现有研究大多为包含青少年亚组的儿童银屑病研究，极少有专门针对银屑病青少年患者健康相关生活质量的独立研究。银屑病青少年不仅面临与成年银屑病患者相似的疾病挑战，还需承受健康青少年群体所固有的特殊复杂处境。现有研究多采用通用儿童健康相关生活质量评估量表PedsQL 4.0，或是基于成人问卷改编的皮肤病专科评估工具。目前仅有一种针对银屑病的专用评估工具，且仅适用于头皮银屑病。<i>结论：</i>皮肤科医师与全科医师均应针对银屑病青少年患者的可见皮肤皮损及合并症开展治疗，同时需重视银屑病对其造成的心理社会影响。联合使用通用型与皮肤病专科型健康相关生活质量问卷，可帮助医师更好地评估疾病的影响，并及时识别患者随时间推移出现的病情改善或功能受损情况。