PROMIS Depression 8a in Environmental influences on Child Health Outcomes (ECHO)-wide Cohort - 2nd Release

PROMIS Depression 8a
Study Description
The National Institutes of Health launched the Environmental influences on Child Health Outcomes (ECHO) initiative in September 2016. The Program focuses on five pediatric outcome areas: obesity, neurodevelopment, upper and lower airways, pre-, peri-, and postnatal outcomes, and positive health. The ECHO-wide Cohort Study, presented here, incorporates longitudinal data on a growing 30,000 pregnancies and 50,000 children from 69 pediatric cohorts to investigate how exposure to environmental factors — including physical, chemical, biological, social, behavioral, natural, and built environments — impact child health and development. By bringing data together into one large ECHO-wide Cohort, scientists can address questions that no single cohort, or a few working together, can answer. Most of the cohorts existed prior to ECHO, bringing a wealth of extant data for compilation and harmonization, in addition to standardized collection of new essential and recommended data elements. As of August 31, 2022, 32,311 pregnancies (among 21,801 pregnant persons) and 30,904 children agreed to participate in new ECHO-wide Cohort data collection. Longitudinal data are collected for pregnancies and life stages of the child to 21 years of age.

PROMIS Depression 8a
研究概况
美国国立卫生研究院(National Institutes of Health)于2016年9月启动了儿童健康结局环境影响(Environmental influences on Child Health Outcomes)计划（以下简称ECHO）。该计划聚焦五大儿科结局领域：肥胖、神经发育、上下呼吸道健康、产前、围产期及产后结局，以及积极健康状态。
本次展示的全ECHO队列研究整合了来自69个儿科队列的纵向数据(longitudinal data)，涵盖不断扩容的3万余例妊娠及5万名儿童，旨在探究物理、化学、生物、社会、行为、自然及建成环境(built environments)等各类环境因素暴露对儿童健康与发育的影响。通过将多源数据整合为大型全ECHO队列，科研人员得以解答单个队列或少数队列联合研究无法触及的科学问题。
多数队列在ECHO计划启动前便已建立，因此除了可标准化采集新增的必要及推荐数据项之外，还可提供大量可供整合与统一处理的现存数据。截至2022年8月31日，共有32311例妊娠（涉及21801名妊娠个体）及30904名儿童同意参与全ECHO队列的新增数据采集工作。研究将针对妊娠全程及儿童直至21岁的各生命阶段采集纵向数据。