Association of gut and oral microbiome with Alzheimer's disease in Puerto Ricans

The most common cause of dementia, Alzheimer's disease (AD), is increasing worldwide and Puerto Ricans have the highest disease and mortality rates compared to other ethnicities. This study explores the gut and oral microbiome composition associated to AD in Hispanics and its relation to APOE variant expression. A better understanding of the gut oral microbiomes composition and structure in high-risk Puerto Rican patients with AD will be an invaluable approach for the future development of gut microbiota-associated diagnostic biomarkers and modulation-based therapeutic interventions.

阿尔茨海默病（Alzheimer's disease, AD）是最常见的痴呆病因，其全球发病率呈逐年上升趋势，而波多黎各裔人群的患病率与死亡率均高于其他族群。本研究聚焦西班牙裔人群中与阿尔茨海默病相关的肠道及口腔微生物组构成，并探讨其与载脂蛋白E（APOE）变异体表达的关联。对高风险波多黎各裔阿尔茨海默病患者的肠道与口腔微生物组构成及结构进行更为深入的解析，将为未来开发基于肠道菌群的诊断生物标志物以及基于菌群调控的治疗干预手段提供极具价值的研究路径。