Comparison of the transcriptional changes in dorsal root ganglion between paclitaxel and oxaliplatin induced peripheral neuropathic pain in rats. Comparison of the transcriptional changes in dorsal root ganglion between paclitaxel and oxaliplatin induced peripheral neuropathic pain in rats

In this study, we screened the differentially expressed genes (DEGs) in dorsal root ganglion between paclitaxel and oxaliplatin induced peripheral neuropathic pain in rats. Overall design: Paclitaxel (2.0 mg/kg dissolved in DMSO and serially diluted in saline, Dalian Meilun Biology Technology Co. Ltd, China) and Oxaliplatin (2.4 mg/kg dissolved in 5.0% glucose solution, Dalian Meilun Biology Technology Co. Ltd., China) was injected intraperitoneally to induce peripheral neuropathic pain.

本研究筛选了大鼠紫杉醇（paclitaxel）与奥沙利铂（oxaliplatin）诱导的周围神经病理性疼痛模型背根神经节（dorsal root ganglion）中的差异表达基因（differentially expressed genes, DEGs）。
实验设计：将紫杉醇（2.0 mg/kg，溶于二甲基亚砜（DMSO）后经生理盐水梯度稀释，购自中国大连美仑生物技术有限公司（Dalian Meilun Biology Technology Co. Ltd））与奥沙利铂（2.4 mg/kg，溶于5.0%葡萄糖溶液，购自中国大连美仑生物技术有限公司（Dalian Meilun Biology Technology Co. Ltd.））通过腹腔注射给药，以诱导周围神经病理性疼痛模型。