Effect of telmisartan on prostate carcinogenesis in TRAP rats. Rattus norvegicus

We investigate the direct effects of ARBs on prostate cancer growth and progression. Overall design: A total of 36 heterozygous male TRAP rats of 3 weeks of age were randomly divided into three groups. Rats in group 1 as a control received basal diet and tap water. The rats in groups 2 and 3 continuously received 2 or 10 mg/kg/day telmisartan in drinking water for 12 weeks, respectively. Total RNAs of both control and telmisartan (10 mg/kg/day) were applied to microarray analysis.

本研究旨在探讨血管紧张素II受体拮抗剂（Angiotensin II Receptor Blockers，ARBs）对前列腺癌生长与进展的直接作用。实验设计概述：共选取36只3周龄的杂合子雄性TRAP大鼠，随机分为三组。第1组为对照组，饲喂基础饲料并饮用自来水；第2组与第3组大鼠分别在饮水中持续给予2 mg/kg/天或10 mg/kg/天的替米沙坦（telmisartan），干预周期为12周。分别提取对照组与10 mg/kg/天替米沙坦干预组的总RNA，开展基因芯片（microarray）分析。