The unique role of GATA1s in Down syndrome acute megakaryocytic leukemia biology and therapy

ChEBI2012-05-31 更新2026-07-21 收录

唐氏综合征相关白血病

GATA1基因功能

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The unique role of GATA1s in Down syndrome acute megakaryocytic leukemia biology and therapy

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2012-05-31

The unique role of GATA1s in Down syndrome acute megakaryocytic leukemia biology and therapy

急性巨核细胞白血病

GATA1基因功能

Microarray gene expression profiling of lentivirus shRNA knockdown of the GATA1 gene in a DS AMkL cell line, CMK (harbors a mutated GATA1 gene and only expresses GATA1s). Cell culture samples from two

NIAID Data Ecosystem50

Deciphering the synergy of RUNX1 with GATA1s mutation in trisomy 21 associated leukemogenesis. RUNX1 isoforms in leukemogenesis

唐氏综合征相关白血病

RUNX1亚型调控

Aneuploidy and structural aberrations of chromosome 21 (Hsa21) are most frequent in acute myeloid leukemia. However, it remained largely unknown, why leukemic blasts select for amplifications of Hsa21

NIAID Data Ecosystem40

Global chromatin occupancy and epigenetic signature analysis reveal new insights into the function of GATA1 N-terminus in erythropoiesis. Global chromatin occupancy and epigenetic signature analysis reveal new insights into the function of GATA1 N-terminus in erythropoiesis

红系生成调控

GATA1基因功能

Mutations in GATA1, which lead to expression of the GATA1s isoform that lacks the GATA1 N-terminus, are seen in patients with Diamond-Blackfan Anemia (DBA). In our efforts to better understand the con

NIAID Data Ecosystem30

Overexpression of GATA1 Confers Resistance to Chemotherapy in Acute Megakaryocytic Leukemia

化疗耐药机制

GATA1基因功能

It has been previously shown that acute myeloid leukemia (AML) patients with higher levels of GATA1 expression have poorer outcomes. Furthermore, pediatric Down syndrome (DS) patients with acute megak

NIAID Data Ecosystem40

Supplementary Table 1 from Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia

唐氏综合征相关白血病

MAPK靶向治疗

Characteristics of the B-ALL cohort

NIAID Data Ecosystem30