Indole Diterpenoid Synthetic Studies. Construction of the Heptacyclic Core of (−)-Nodulisporic Acid D

Construction of the heptacyclic core of (−)-nodulisporic acid D, a representative member of a recently discovered class of architecturally
complex, ectoparasiticidal indole alkaloids, has been achieved. The modular synthetic strategy comprises an expedient, stereocontrolled
synthesis of a tricyclic western hemisphere, in conjunction with union of an eastern hemisphere, exploiting the 2-substituted indole synthetic
protocol introduced and developed in our laboratory.

针对近期发现的一类结构复杂精巧、兼具体外杀虫活性的吲哚生物碱家族的代表性成员(-)-结节孢酸D（(-)-nodulisporic acid D），其七环核心的构建已成功完成。本研究采用的模块化合成策略，包含一条便捷且立体可控的三环西半片段合成路径，并通过偶联反应接入东半分子片段，同时利用本实验室首创并开发的2-取代吲哚合成方法学完成整体拼接。