Polymyxin resistance in Klebsiella pneumoniae

Polymyxin resistance (PR) is an emerging threat. We sequenced K. pneumoniae isolates from a single healthcare system from 2011 - 2018. We noted multiplicity of genomic alterations leading to PR in clinical Klebsiella pneumoniae, both within individual patients and isolate clusters. Polymyxin exposure rather than transmission played a key role in spread of PR.

多粘菌素耐药（Polymyxin Resistance, PR）已成为新兴的严峻公共卫生威胁。本研究对2011年至2018年间某单一医疗系统内分离得到的肺炎克雷伯菌（Klebsiella pneumoniae）菌株进行了测序。研究观察到，临床肺炎克雷伯菌中存在多种可导致多粘菌素耐药的基因组变异，此类变异既存在于单个患者体内，也存在于菌株聚类群体中。多粘菌素暴露而非菌株传播，在多粘菌素耐药性的扩散过程中发挥了关键作用。