Table_2_Move for Life an intervention for inactive adults aged 50 years and older: a cluster randomised feasibility trial.DOCX

BackgroundMove for Life (MFL) is a theory-informed intervention that was developed to augment established physical activity (PA) programmes and enable inactive adults aged 50 years and older to be more active. This study examined the feasibility of MFL and sought to provide evidence of its potential for improving PA and associated health outcomes.
MethodsA 3-arm cluster randomised feasibility trial compared MFL intervention, usual provision (UP) and control (CON) groups at baseline (T0), post-intervention (T1, at 8, 10 or 12- weeks) and 6-month follow up (T2). We used purposive sampling strategies to recruit participants according to characteristics of interest. Feasibility outcomes assessed recruitment, fidelity, adherence, retention and data completion rates based on pre-set criteria. Primary outcomes were accelerometer-based moderate-to-vigorous intensity PA (MVPA) and self-reported compliance with physical activity guidelines (PAGL). Secondary outcomes included light intensity PA (LiPA), standing time, sedentary time, body composition (adiposity), physical function and psychological well-being. We used linear mixed models (continuous outcomes) or generalized estimated equations (categorical outcomes) to estimate group differences over time in the study outcomes.
ResultsProgression criteria for feasibility outcomes were met, and 733 individuals were recruited. Considering a 6-month period (T0-T2), while self-reported compliance with PAGL increased in MFL relative to UP and CON and in UP relative to CON, standing time decreased in MFL relative to CON and sedentary time increased in the latter compared to UP. Waist circumference decreased in MFL relative to UP and CON. MFL outperformed UP in the Timed Up and Go Test while MFL and UP increased the distance covered in the Six-Minute Walk Test compared to CON. Psychological well-being increased in MFL relative to CON (all p < 0.05).
ConclusionFindings show that MFL is feasible, while data are promising with regards to the potential of improving community PA programmes for adults aged 50 or more years.
Clinical trial registrationhttps://www.isrctn.com/Registration#ISRCTN11235176.

背景：终身背景运动（BackgroundMove for Life，MFL）是一项基于理论的干预方案，旨在优化现有身体活动（physical activity，PA）项目，帮助50岁及以上的久坐成年人提升活动量。本研究评估了MFL的可行性，并旨在为其改善身体活动及相关健康结局的潜力提供证据支持。

方法：本研究采用三整群随机可行性试验设计，在基线（T0）、干预后（T1，即8、10或12周）及6个月随访（T2）三个时间点，对比MFL干预组、常规服务（usual provision，UP）组与对照组（control，CON）的差异。研究采用目的性抽样策略，根据预设关注的特征招募受试者。可行性结局指标基于预设标准，评估招募情况、干预保真度、依从性、随访保留率及数据完整率。主要结局指标包括基于加速度计检测的中等到高强度身体活动（moderate-to-vigorous intensity PA，MVPA），以及自我报告的身体活动指南依从性（physical activity guidelines，PAGL）。次要结局指标涵盖低强度身体活动（light intensity PA，LiPA）、站立时间、久坐时间、身体成分（体脂水平）、身体功能及心理健康状况。研究采用线性混合模型（针对连续性结局）或广义估计方程（针对分类结局），估算各结局指标随时间推移的组间差异。

结果：可行性结局的进展标准均已达成，共招募733名受试者。在6个月周期（T0-T2）内，自我报告的PAGL依从性在MFL组较UP组与CON组均有所提升，且UP组较CON组亦有提升；MFL组的站立时间较CON组有所降低，而CON组的久坐时间较UP组有所升高。MFL组的腰围较UP组与CON组均有所降低。在计时起立行走测试中，MFL组表现优于UP组；而与CON组相比，MFL组与UP组的6分钟步行试验行走距离均有所增加。MFL组的心理健康状况较CON组有所改善（所有p值均<0.05）。

结论：研究结果表明，MFL具有可行性，且其改善50岁及以上成年人社区身体活动项目的潜力数据令人振奋。

临床试验注册：https://www.isrctn.com/Registration#ISRCTN11235176