DataSheet_1_Pathology Reporting in Neuroendocrine Neoplasms of the Digestive System: Everything You Always Wanted to Know but Were Too Afraid to Ask.docx

During the 5th NIKE (Neuroendocrine tumors Innovation in Knowledge and Education) meeting, held in Naples, Italy, in May 2019, discussions centered on the understanding of pathology reports of gastroenetropancreactic neuroendocrine neoplasms. In particular, the main problem concerned the difficulty that clinicians experience in extrapolating relevant information from neuroendocrine tumor pathology reports. During the meeting, participants were asked to identify and rate issues which they have encountered, for which the input of an expert pathologist would have been appreciated. This article is a collection of the most rated questions and relative answers, focusing on three main topics: 1) morphology and classification; 2) Ki67 and grading; 3) immunohistochemistry. Patient management should be based on multidisciplinary decisions, taking into account clinical and pathology-related features with clear comprehension between all health care professionals. Indeed, pathologists require clinical details and laboratory findings when relevant, while clinicians require concise and standardized reports. In keeping with this last statement, the minimum requirements in pathology datasets are provided in this paper and should be a baseline for all neuroendocrine tumor professionals.

2019年5月于意大利那不勒斯举办的第5届神经内分泌肿瘤知识与教育创新（NIKE，Neuroendocrine tumors Innovation in Knowledge and Education）会议上，与会者围绕胃肠胰神经内分泌肿瘤（gastroenteropancreatic neuroendocrine neoplasms）的病理报告解读展开讨论。其中核心议题为临床医师难以从神经内分泌肿瘤病理报告中提取有效相关信息。会议期间，主办方邀请参会者梳理并评级其曾遇到的、需借助病理专家意见方能解决的各类问题。本文汇总了获评级最高的若干问题及对应解答，聚焦三大核心主题：1. 形态学与分类；2. Ki67指数与分级；3. 免疫组化。患者管理应基于多学科决策，需充分考量临床与病理相关特征，并确保所有医疗从业人员间的沟通清晰顺畅。诚然，病理医师在必要时需获取临床细节与实验室检测结果，而临床医师则期望获得简洁规范的病理报告。契合这一目标，本文明确了病理数据集的最低要求，可作为所有神经内分泌肿瘤相关从业人员的工作基准。