Salvianolic Acid B Attenuates Cellular Senescence and Age-Related Sarcopenia via Dual mTOR/TP53INP2-Autophagy Regulation

Research has demonstrated that SAB effectively alleviates the cellular senescence phenotype. It was observed that SAB reduces SASP expression through modulation of the mTOR pathway. Additionally, SAB was found to decrease cellular ROS levels and enhance ATP production. In vitro studies further revealed that SAB ameliorates age-related sarcopenia, potentially through promoting TP53INP2 expression to enhance autophagy. These findings provide novel insights into the potential applications of SAB in the field of anti-aging research.

已有研究证实，SAB可有效缓解细胞衰老表型。研究观察到，SAB可通过调控雷帕霉素靶蛋白（mTOR）通路，降低衰老相关分泌表型（SASP）的表达水平。此外，研究还发现SAB可降低细胞内活性氧（ROS）水平，并提升三磷酸腺苷（ATP）的生成量。体外实验进一步揭示，SAB可改善年龄相关性肌少症，其潜在机制可能通过上调TP53INP2的表达以增强细胞自噬。上述研究结果为SAB在抗衰老研究领域的潜在应用提供了全新的理论视角。