Comparison of Tumor and Non-Tumor Glycans Detected in Hepatocellular Carcinoma Tissue Microarrays.

A list of 26 monoisotopic ions that were identified in the HCC TMA were cross-referenced against a library of known glycan m/z values listed in this paper or our previous paper (21). The ability of individual glycan ions to distinguish tumor tissue from non-tumor tissue were assessed using AuROC, log2-fold changes (tumor/non-tumor), and p-values. Localization of m/z = 2393.95 and m/z = 1743.62 (highlighted in yellow) are depicted in Figure 6.Comparison of Tumor and Non-Tumor Glycans Detected in Hepatocellular Carcinoma Tissue Microarrays.

本研究在肝细胞癌（Hepatocellular Carcinoma, HCC）组织微阵列（Tissue Microarrays, TMA）中鉴定得到26种单同位素离子，并将其与本文及此前一篇论文（参考文献21）中收录的已知聚糖质荷比（m/z）数据库进行交叉参照。本研究采用受试者工作特征曲线下面积（Area Under the Receiver Operating Characteristic curve, AUROC）、对数2倍变化倍数（肿瘤/非肿瘤）以及p值，评估了单种聚糖离子区分肿瘤组织与非肿瘤组织的效能。质荷比为2393.95与1743.62的离子（以黄色高亮标注）的定位情况详见图6：《肝细胞癌组织微阵列中检测到的肿瘤与非肿瘤聚糖对比》。