Liver in NOG-TKm30 mice: Control vs acetoaceto-o-toluidide treatment

The gene expression profling between Control and acetoaceto-o-toluidide exposure for 4 weeks in liver of NOG-TKm30 female mice. Female 22-week-old NOG mice expressing HSVtk mutant clone 30 cDNA under the control of mouse transthyretin gene enhancer/promoter (NOG-TKm30 mice) were treated with 0 or 0.3% acetoaceto-o-toluidide (AAOT) for 4 weeks. After treatment, mice were sacrificed, and removed livers. Control and AAOT treatment: 3 control female mice, 3 AAOT-treated female mice, respectively. Mixed 3 samples from each group for each RNA-seq.

本数据集聚焦NOG-TKm30雌性小鼠肝脏组织中，对照组与双乙酰邻甲苯胺（acetoaceto-o-toluidide, AAOT）暴露4周后的基因表达谱分析。选取22周龄的雌性NOG小鼠，其体内携带受小鼠运甲状腺素蛋白（transthyretin）基因增强子/启动子调控的单纯疱疹病毒胸苷激酶（HSVtk）突变体克隆30互补脱氧核糖核酸（cDNA），即NOG-TKm30小鼠；将此类小鼠分别以0%（对照组）与0.3%浓度的双乙酰邻甲苯胺（AAOT）处理4周。处理结束后处死小鼠并摘取肝脏组织。每组各设置3只雌性小鼠：对照组与AAOT处理组分别为3只。每组的3份样本混合后，用于后续RNA测序（RNA-seq）实验。