m6A is required for resolving planarian progenitor identity

Regeneration requires accurate production of missing cell lineages. Cell production is driven by changes to gene expression, which is shaped by multiple layers of regulation. Here, we find that the ubiquitous mRNA base-modification, m6A, is required for proper cell fate choice and cellular maturation in planarian stem cells neoblasts.

再生过程需要精准生成缺失的细胞谱系。细胞生成由基因表达的改变所驱动，而基因表达受多层调控机制塑造。本研究发现，这种普遍存在的mRNA碱基修饰——N6-甲基腺嘌呤（m6A）——对于真涡虫干细胞（neoblasts）的正常细胞命运选择与细胞成熟过程不可或缺。