Lung transcriptomics (mRNA) - contrast

This dataset was generated in an in vivo OECD TG 413 90-days nose-only inhalation study where Sprague-Dawley rats were exposed to either 3R4F cigarette smoke or aerosols of the carbon heated tobacco product (CHTP) 1.2, a heat-not-burn platform. The study contains additional test groups that were examined following a systems toxicology approach (please refer to the study page for more detail on the study design).
The lung transcriptome was characterized using Affymetrix GeneChip® Rat Genome 230 2.0 Array. This dataset contains the statistics resulting from the comparison of treatment and control groups.

本数据集源自一项符合经济合作与发展组织（Organisation for Economic Co-operation and Development, OECD）试验指南413的90天体内仅鼻式吸入暴露试验，试验中斯普拉-道来大鼠（Sprague-Dawley rats）分别暴露于3R4F卷烟烟气，或碳基加热烟草制品（carbon heated tobacco product, CHTP）1.2的气溶胶——该制品属于加热不燃烧（heat-not-burn）平台。本研究设置了额外试验组，并采用系统毒理学（systems toxicology）方法开展相关检测，有关试验设计的详细信息，请参阅研究页面。
本研究采用Affymetrix GeneChip® 大鼠基因组230 2.0阵列对肺转录组（lung transcriptome）进行了表征。本数据集包含处理组与对照组比较后得到的统计分析结果。