Analysis of oxybutynin treatment for hyperhidrosis in patients aged over 40 years

Objective : Our aim was to analyze the effectiveness of oxybutynin for hyperhidrosis treatment in patients over 40 years. Methods : Eighty-seven patients aged over 40 years were divided into two groups. One group consisted of 48 (55.2%) patients aged between 40 and 49 years, and another was composed of 39 (44.8%) patients aged over 50 years (50 to 74 years). A comparative analysis of Quality of Life and level of hyperhidrosis between the groups was carried out 6 weeks after a protocol treatment with oxybutynin. A validated clinical questionnaire was used for evaluation. Results : In the younger age group, 75% of patients referred a “partial” or “great” improvement in level of hyperhidrosis after treatment. This number was particularly impressive in patients over 50 years, in which 87.2% of the cases demonstrated similar levels of improvement. Over 77% of patients in both groups demonstrated improvement in Quality of Life. Excellent outcomes were observed in older patients, in which 87.1% of patients presented “slightly better” (41%) or “much better” (46.1%) improvement. Conclusion : Patients aged over 40 years with hyperhidrosis presented excellent results after oxybutynin treatment. These outcomes were particularly impressive in the age group over 50 years, in which most patients had significant improvement in Quality of Life and in level of hyperhidrosis.

研究目的：本研究旨在分析奥昔布宁（oxybutynin）用于40岁以上多汗症患者治疗的有效性。
方法：本研究纳入87名40岁以上的多汗症患者，将其分为两组。其中一组包含48名患者，占比55.2%，年龄介于40至49岁之间；另一组包含39名患者，占比44.8%，年龄为50岁及以上（50至74岁）。所有患者接受奥昔布宁方案治疗6周后，对两组的生活质量及多汗症严重程度开展对比分析，评估采用经过临床验证的问卷完成。
结果：在较年轻的年龄组中，75%的患者自述多汗症严重程度获得“部分”或“大幅”改善；这一改善率在50岁以上的患者群体中更为亮眼，其中87.2%的病例呈现出同等程度的改善。两组中超过77%的患者生活质量得到提升。老年患者的疗效更为优异，87.1%的患者表现为“略有改善”（41%）或“大幅改善”（46.1%）。
结论：40岁以上的多汗症患者接受奥昔布宁治疗后可获得极佳疗效，这一效果在50岁以上的年龄组中尤为显著，该组多数患者的生活质量及多汗症严重程度均得到明显改善。