Guanine Nucleotide Exchange Factors Involved in Pathogenesis and/or Caspase-1 Activation.

aFor some effector proteins, the Rho GTPase specificity has not been analyzed in sufficient detail; therefore, specificity for additional Rho GTPases not listed is likely for some of the GEFs.bB. pseudomallei causes a wide variety of disease symptoms among different hosts, including pneumonia, gut inflammation, and diarrhea [62].cUpon transfection.dSequence homology data and GEF activity not directly shown.eIpgB1 and IpgB2 were shown to cooperatively contribute to the in vivo phenotype.fC. rodentium and enteropathogenic E. coli share highly homologous forms of Map [63]. The in vivo phenotype was shown with C. rodentium Map, whereas GEF activity was shown experimentally with E. coli Map.

a. 对于部分效应蛋白，其Rho GTP酶（Rho GTPase）特异性尚未得到充分详尽的分析；因此，部分鸟苷酸交换因子（GEF）大概率可识别本列表未收录的其他Rho GTP酶。
b. 类鼻疽伯克霍尔德菌（B. pseudomallei）可在不同宿主中引发多种疾病症状，涵盖肺炎、肠道炎症与腹泻[62]。
c. 转染后。
d. 序列同源性数据与鸟苷酸交换因子活性尚未得到直接验证。
e. 已证实IpgB1与IpgB2可协同影响体内表型。
f. 鼠柠檬酸杆菌（C. rodentium）与肠致病性大肠杆菌（E. coli）拥有高度同源的Map蛋白[63]。已有研究以鼠柠檬酸杆菌的Map蛋白验证了其体内表型，而鸟苷酸交换因子活性则通过大肠杆菌的Map蛋白经实验证实。