Whole genome sequence analysis of bacteriophage infecting mukltidrug resistance virulent Campylobacter species

This study aims to perform whole genome sequence analysis of bacteriophages infecting multidrug-resistant and virulent Campylobacter species, with the goal of elucidating their genetic composition, diversity, and potential therapeutic value. By characterizing phage genomes, the research seeks to identify genes associated with host specificity, lytic activity, and possible antimicrobial resistance determinants, which are critical for evaluating their safety and effectiveness as alternatives to antibiotics. Given the growing concern of multidrug resistance in Campylobacter, a leading cause of foodborne infections worldwide, phage-based strategies provide a promising biocontrol approach to mitigate public health risks. This study is therefore relevant in addressing antimicrobial resistance, advancing phage therapy research, and contributing to the development of novel interventions for the control of Campylobacter in clinical and food production settings.

本研究旨在对感染多重耐药且强毒力弯曲杆菌（Campylobacter）物种的噬菌体（bacteriophages）开展全基因组序列分析，以期阐明其遗传组成、多样性及潜在治疗价值。通过表征噬菌体基因组，本研究旨在筛选出与宿主特异性、裂解活性及潜在抗菌耐药决定因子相关的基因，上述基因对于评估噬菌体作为抗生素替代疗法的安全性与有效性至关重要。鉴于弯曲杆菌是全球食源性感染的主要致病菌，且其多重耐药性问题日益引发关注，基于噬菌体的防控策略为降低公共卫生风险提供了极具前景的生物防治路径。因此，本研究对于应对抗菌耐药性挑战、推进噬菌体疗法研究，以及开发用于临床与食品生产场景中弯曲杆菌防控的新型干预手段，均具有重要的现实意义。