Supplementary Material for: Nephroblastoma in older adult. Case Report and review of literature

Abstract
Introduction: Nephroblastoma, or Wilms' tumor, is a malignant renal neoplasm commonly found in children, is extremely rare in adults representing only 0.5% of all renal neoplasms. Adult Wilms tumor is rare, to our knowledge fewer than 300 cases have been reported in the English literature to date. However, in older adults after 60 years of age, only less than 45 cases have been reported. For this reason, treatment guidelines in adults still are lacking. Prognosis in nephroblastoma for adult patients is found to be worse than in children.
Case presentation: We report the case of a 65-year-old female with lumbar fossa mass, flank pain and hematuria, and pathologic diagnosis of Wilms tumor. We performed nephrectomy. No adjuvant treatment was given. Our patient remains asymptomatic and without evidence of recurrence 12 months after the surgery.
Conclusion: Nephroblastoma in the elderly presents different clinical behavior and prognosis compared to nephroblastoma in children.

摘要
引言：肾母细胞瘤（Nephroblastoma，又称威尔姆斯瘤（Wilms' tumor））是儿童常见的恶性肾肿瘤，在成人中极为罕见，仅占所有肾肿瘤的0.5%。据我们所知，截至目前英文文献中报道的成人肾母细胞瘤病例不足300例，其中60岁及以上老年患者的报道病例更是不足45例。正因如此，成人肾母细胞瘤的治疗指南仍存在空白。临床研究显示，成人肾母细胞瘤患者的预后较儿童患者更差。
病例报告：本文报告1例65岁女性患者，临床表现为腰窝肿块、胁腹疼痛及血尿，经病理诊断确诊为威尔姆斯瘤。患者接受了肾切除术，未行辅助治疗。术后12个月随访，患者仍无临床症状，未发现肿瘤复发迹象。
结论：与儿童肾母细胞瘤相比，老年患者罹患的肾母细胞瘤在临床行为及预后方面存在明显差异。