Table 2_Understanding the treatment of acute pancreatitis and its complications -a database for assessing traditional Chinese medicine use.xlsx

IntroductionIntegrative medicine combining traditional Chinese medicine (TCM) with biomedicine has become a notable approach for treating acute pancreatitis (AP). However, the absence of a comprehensive and reliable database to store and organize TCM-related data for the prevention and treatment of AP presents a significant challenge for the development of herbal medicines. To develop a comprehensive, user-friendly platform for browsing, querying, and analyzing TCM-related data for treating AP.
MethodsTCM-related data for treating AP were systematically extracted from the literature and established databases. The front-end interface was developed using HyperText Markup Language, Cascading Style Sheets, and JavaScript to enhance user experience. The back-end employed Hypertext Preprocessor and My Structured Query Language for improved performance and security. The Smarty template engine was utilized to separate the front-end and back-end, facilitating efficient updates to the TCMAP platform.
Results and discussionThe current version of the TCMAP includes: (i) documentation of 200 evidence-based TCM formulations, with comprehensive details on clinical applications, targets related to AP, and target pathway enrichment analysis, including 449 herbs; (ii) records of 58 natural metabolites, involving extensive information on their potential targets and pharmacological properties; and (iii) integration with a web server enables users to conduct similarity and enrichment analyses of input prescriptions based on herbs, metabolites, and genes. Furthermore, TCMAP also supports discovering anti-AP herb pairs with similar metabolites and targets. Network analysis further provides users with the intrinsic properties of anti-AP formulations. The TCMAP provides a robust data platform for predicting new metabolites and exploring the potential mechanisms of TCM in treating AP. The TCMAP is accessible at https://cellknowledge.com.cn/tcmap.

引言：将传统中医药（Traditional Chinese Medicine, TCM）与生物医学相结合的整合医学，已成为治疗急性胰腺炎（Acute Pancreatitis, AP）的重要方案。然而，目前缺乏用于存储和整理AP防治相关中医药数据的全面可靠数据库，这已成为中药研发领域面临的重大挑战。为此，本研究旨在开发一款全面易用的平台，用于浏览、查询和分析AP治疗相关的中医药数据。
方法：本研究从公开文献及已建成数据库中系统提取AP治疗相关的中医药数据。前端界面采用超文本标记语言（HyperText Markup Language, HTML）、层叠样式表（Cascading Style Sheets, CSS）及JavaScript开发，以优化用户体验。后端采用超文本预处理器（Hypertext Preprocessor, PHP）及My Structured Query Language（MySQL）搭建，以提升平台性能与安全性。本研究使用Smarty模板引擎实现前后端分离，便于TCMAP平台的高效更新迭代。
结果与讨论：当前版本的TCMAP平台包含以下内容：（1）收录200个循证中医药方剂，涵盖其临床应用、AP相关作用靶点及靶点通路富集分析等全面信息，涉及449味中药材；（2）收录58种天然代谢物，包含其潜在作用靶点及药理学特性等详细信息；（3）集成Web服务器功能，支持用户基于中药材、代谢物及基因对输入方剂进行相似性与富集分析。此外，TCMAP平台还支持挖掘具有相似代谢物与作用靶点的抗AP药对。网络分析功能可向用户展示抗AP方剂的内在属性特征。TCMAP平台为新型代谢物预测及中医药治疗AP的潜在机制探索提供了可靠的数据支撑。用户可通过https://cellknowledge.com.cn/tcmap访问该平台。