Characterization of five lead candidates selected for in vivo testing.

In vitro activity on P. falciparum 3D7, NTS, adult S. mansoni, cytotoxicity on MRC5-cells, and pharmacokinetic parameters* of 5 active compounds selected for in vivo studies identified in 2 parallel screens at the Swiss TPH and LSHTM.PK parameters are unpublished data, In vitro activity on P. falciparum 3D7 and cytotoxicity on MRC5-cells can be found at http://www.mmv.org/research-development/malaria-box-results.

本数据集涵盖了瑞士热带和公共卫生研究所（Swiss TPH）与伦敦卫生与热带医学院（LSHTM）开展的两项平行筛选中鉴定出的5种活性化合物的相关研究数据，这5种化合物已被选定开展体内实验。数据集包含的具体内容包括：针对恶性疟原虫（Plasmodium falciparum）3D7毒株、NTS以及曼氏血吸虫（Schistosoma mansoni）成虫的体外活性数据，MRC5细胞的细胞毒性数据，以及上述5种活性化合物的药代动力学参数*。其中药代动力学参数为未发表数据；针对恶性疟原虫3D7毒株的体外活性数据与MRC5细胞的细胞毒性数据，可通过http://www.mmv.org/research-development/malaria-box-results查询获取。